Royal Air Force Typhoon FGR4s have joined forces with French aircraft in a combined operation targeting an subterranean weapons facility in Syrian territory used by the IS group, per a report from the British defence ministry.
The site, identified by reconnaissance, was thought to be housing weapons and explosive materials, the release indicated, and was located in hills just north of the historic site of Palmyra in central Syria.
"Our aircraft utilized Paveway IV guided bombs to hit a series of access tunnels providing entry to the facility... early reports suggest the objective was successfully hit," the MoD said.
There was no sign of any civilian impact in the operation on Saturday evening and all the aircraft returned safely, the defence officials confirmed.
The Typhoon fighters were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as ISIS - established extremist governance over large swathes of both Syria and Iraq prior to its 2019 collapse.
"This operation demonstrates British leadership, and resolve to work closely with our allies, to eradicate any revival of Daesh and their harmful and extremist ideologies in the area," UK Defence Secretary John Healey said.
British military aircraft have performed patrols over Syrian airspace to "deter any attempted comeback" of IS subsequent to its defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I must thank the personnel of the UK armed forces who took part in this strike for their professionalism and their courage," Healey added. "They were part of a great many UK service members deployed over the holidays. This mission, to remove militants who pose a risk to our safety, shows how UK forces are ready to step up, throughout the year, protecting the UK within its borders and powerful internationally."
During December, the American forces conducted what it described as a "major assault" targeting IS targets in Syria, after an assault killed two US servicemembers and a civilian interpreter in Palmyra.
The United Nations estimates Islamic State still boasts an estimated 5,000 to 7,000 combatants in Syria and Iraq.